Our Technology

We utilise epigenomics to provide complementary insights to existing genomic information

Epigenomics examines modifications in gene expression that occur independently of changes in the DNA sequence. It focuses on exploring the mechanisms that influence gene regulation, which leads to downstream effects on gene expression. Unlike genomics, which studies the DNA sequence itself, epigenomics studies reversible modifications that impact gene activity without alteration of the underlying DNA sequence, rendering them undetectable through genomic assays.

Two of the most characterised epigenomic modifications are DNA methylation and histone modifications. DNA methylation involves the addition of methyl groups to DNA bases, primarily cytosines, while histone modifications encompass chemical alterations to histone proteins, changing the chromatin structure and influencing gene expression levels.

Auristone’s core technology centres around histone modifications while most other epigenomic companies focus on DNA methylation.

Epigenomic changes can drive carcinogenesis by influencing gene expression

Genomic information is not sufficient

Altered Gene Expression

Cancer Development

Post-translational modifications of histones influence protein-DNA interactions and modify the physical properties of chromatin

Histone modifications occurring on regulatory sites (promoters and enhancers) can alter gene expression patterns

Potential cancer development can arise when transcriptional activities and gene expression levels of oncogenes are affected

Histone Modifications

Post-translational modifications of histones influence protein-DNA interactions and modify the physical properties of chromatin

Altered Gene Expression

Histone modifications occurring on regulatory sites (promoters and enhancers) can alter gene expression and alternate isoform expression patterns

Cancer Development

Potential cancer development can arise when transcriptional activities and gene expression levels of oncogenes are affected

Why use epigenomics?

ChIP-Seq

Chromatin Immunoprecipitation Sequencing (ChIP-Seq) is a technique used to study histone modifications. As each distinct histone mark plays a specific role in influencing gene expression, ChIP-Seq can be employed to examine these histone marks and to survey epigenomic landscapes, revealing insights into gene expression and activity.

RNA-Seq

RNA Sequencing (RNA-Seq) provides information about the actual transcriptional activity of genes by quantifying their expression levels. The insights obtained through RNA-Seq can be used to complement the genomic information derived from DNA Sequencing (DNA-Seq). Additionally, RNA-Seq facilitates the discovery of novel transcripts and identification of alternatively spliced genes.

Our technology allows us to report novel insights with clinical significance

Histone marks located within regulatory regions of DNA can influence gene expression patterns. ChIP-Seq can be used to detect these histone marks while RNA-Seq can be used to explore the effects of specific histone marks on gene expression. This synergy can enable the discovery of novel insights with notable clinical relevance.

ChIP-Seq facilitates the discovery of novel regulatory markers, which includes regions of low expression levels that are not discernible in standard RNA-Seq.

Our Technology

We utilise epigenomics to provide complementary insights to existing genomic information

Epigenomic changes can drive carcinogenesis by influencing gene expression

Genomic information is not sufficient

Altered Gene Expression

Cancer Development

Histone Modifications

Altered Gene Expression

Cancer Development

Why use epigenomics?

ChIP-Seq

RNA-Seq

Our technology allows us to report novel insights with clinical significance

ChIP-Seq facilitates the discovery of novel regulatory markers, which includes regions of low expression levels that are not discernible in standard RNA-Seq.

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